食品安全计量研究室

任务与职责

研究建立国家食品与农产品溯源计量体系；建立、保存、维护食品安全领域计量基标准，开展食品安全计量领域的基础性和前沿技术研究，研制标准物质；开展量值传递和溯源工作，组织和参加国际比对、开展国内实验室能力评价等。

研究团队

研究人员19人，其中博士7人，博士后1人，硕士6人。

研究领域

研究内容与技术

◇有害残留计量技术与标准物质

◇营养成分计量技术与标准物质

◇食品添加剂计量技术与标准物质

◇无机元素及形态计量技术与标准物质

◇同位素测量与追溯技术与标准物质

◇高准确度测量和样品前处理技术

◇食品快速检测技术

◇食品基体标准物质制备技术

研究成果

食品分析标准物质：农兽药、食品添加剂、营养成分、违禁添加物等400多种纯品、溶液和基体标准物质。每年发售标准物质近10万单元。

食品分析标准物质数量图（高纯物质/溶液391种）                         食品分析标准物质数量图（食品基体标准物质93种）

 

国际比对与国际互认

主导和参加食品领域CCQM、APMP以及中日韩合作（ACRM）的国际比对。2018年已有132项国家校准与测量能力（CMC）获得国际互认（BIPM KCDB）。

 

WG	Reference No.	Description
CCQM-IAWG	CCQM-K75	海藻中有害重金属/Toxic metals in algae
CCQM-OAWG	CCQM-P122	猪肉中氯霉素
CCQM-IAWG	CCQM-K97	鱼肉和溶液中的砷甜菜碱成分测量
CCQM-OAWG	CCQM-K103	奶粉中三聚氰胺含量测定
CCQM-IAWG	CCQM-K108	大米粉中总砷与砷形态成分测量
APMP-TCQM	APMP.QM-P19	奶粉中三聚氰胺
APMP-TCQM	APMP.QM-P23	橙汁中苯甲酸的测定
APMP-TCQM	APMP.QM-S6	猪肉中克伦特罗
APMP-TCQM	APMP.QM-S8	酱油中苯甲酸、尼泊金甲酯、尼泊金丁酯
APMP-TCQM	APMP.QM-S10	膳食补充剂中元素分析
CCQM-IAWG	CCQM-K124	饮用水中微量元素
CCQM-IAWG	CCQM-K125	婴儿配方乳粉中元素
CCQM-IAWG	CCQM-K140	蜂蜜中碳稳定同位素丰度比
CCQM-OAWG	CCQM K141	牛肉中恩诺沙星、磺胺嘧啶
CCQM-IAWG	CCQM-K145	牛肝中营养和有害元素
CCQM-OAWG	CCQM K146	橄榄油中苯并芘含量测定
ACRM WG1	Project No. 23	大蒜粉中元素分析

表1 组织和参加的部分国际比对

国际比对结果

技术支撑与保障服务

◇ 服务对象：市场监管总局、国家卫生健康委员会、农业农村部、商务部、海关总署等。

✔奥运食品检测用标准物质研制

✔制定原料乳中三聚氰胺快速检测国家标准

✔新西兰奶粉“1080”投毒事件

✔2015年北京国际世界田径锦标赛食品安全保障

✔食药总局食品检测机构遴选评价

✔奶粉检测结果不一致仲裁评价

✔承担总局本级食品安全承检机构考核办公室任务

表2 食品检测实验室质量控制及能力评价

国际合作

与美国NIST合作开展海藻中砷糖成分标准物质的研究

与英国LGC合作开展膳食补充剂中铬元素形态成分标准物质的研究

与国际计量局（BIPM）合作开展真菌毒素纯度标准物质的绝对定量定值技术研究 与BIPM共同主导国际合作项目“Mycotoxin Metrology Capacity Building and Knowledge Transfer (MMCB&KT)”。

派4名科学家赴BIPM合作研究，建立真菌毒素测量溯源基础能力。并对巴西、阿根廷、南非、肯尼亚、泰国、突尼斯、乌拉圭、哥伦比亚等国技术人员，开展真菌毒素计量能力培训，累计42 人月。

与日本NMIJ、韩国KRISS合作开展食品基体标准物质研制

国际援助项目“Metrology – Enabling Developing Economies in Asia”（MEDEA）中，为菲律宾、越南、泰国等发展中国家提供2期共4人次，累计12人月的兽药残留质谱分析技术培训

2014-2019年部分代表性SCI论文

1.Li, X.; Ma, W.; Li, H.; Bai, Y.; Liu, H., Metal-organic frameworks as advanced sorbents in sample preparation for small organic analytes. Coordination Chemistry Reviews, 2019. 397, 1-13. IF=14.499, 1区

2.Chi Zhang, Xiaomin Li, Hongmei Li, Yanling Chen, Tingting Ma, Xiuqin Li, Yan Gao, Qinghe Zhang *, Determination of polybrominated diphenyl ethers in fish tissue using gas chromatography-isotope dilution tandem inductively coupled plasma mass spectrometry with a mass-shift mode. Analytica Chimica Acta, 1075 (2019) 38-48. IF=5.123,2区

3.Li, X.; Li, H.; Ma, W.; Guo, Z.; Li, X.; Song, S.; Tang, H.; Li, X.; Zhang, Q., Development of precise GC-EI-MS method to determine the residual fipronil and its metabolites in chicken egg. Food Chemistry, 2019, 281, 85-90. IF=4.946, 2区

4.Gao, Y.; Liang, Y.; Gao, K.; Wang, Y.; Wang, C.; Fu, J.; Wang, Y.; Jiang, G.; Jiang, Y., Levels, spatial distribution and isomer profiles of perfluoroalkyl acids in soil, groundwater and tap water around a manufactory in China. Chemosphere, 2019, 227, 305-314. IF=4,43,2区

5.Guo, Zhen; Li, Xianjiang; Li, Hongmei, Certified Reference Materials and Metrological Traceability for Mycotoxin Analysis. Journal of AOAC International, 2019. DOI: https://doi.org/10.5740/jaoacint.19-0125. IF=1.45, 4区

6.Yan Zhang, Xiu Qin Li, Hong Mei Li, Qing He Zhang, Yan Gao, Xian Jiang Li., Antibiotic residues in honey: A review on analytical methods by liquid chromatography tandem mass spectrometry, Trends in Analytical Chemistry, 110(2019) 344-356.

7.Gao Yan, Li Xiaomin, Li Xiuqin, Zhang Qinghe, Li Hongmei. Simultaneous determination of 21 trace perfluoroalkyl substances in fish by isotope dilution ultrahigh performance liquid chromatography tandem mass spectrometry, Journal of Chromatography B, 2018, 1084: 45-52

8.Gao Yan, Zhang Qinghe, Li Xiaomin, Li Xiuqin, Li Hongmei. Simultaneous determination of legacy and emerging per- and polyfluoroalkyl substances in fish by QuEChERS coupled with ultrahigh performance liquid chromatography tandem mass spectrometry, Analytical Methods, 2018, 10: 5715-5722.

9.Li, X.; Li, H.; Ma, W.; Guo, Z.; Li, X.; Li, X.; Zhang, Q., Determination of patulin in apple juice by single-drop liquid-liquid-liquid microextraction coupled with liquid chromatography-mass spectrometry. Food Chemistry, 2018, 257, 1-6.

10.Xiaomin Li, Qinghe Zhang, Ling, Chen, Jiaying Zhao, Hongmei Li，Determination of 16 phthalate esters in sesame oil by isotope dilution liquid chromatography with tandem mass spectrometry，Analytical Methods, 2018, 10, 3197-3206.

11.Shuan Liu, Xiaomin Li*, etc. Quantification of Estrogens in Infant Formula by Isotope Dilution Liquid Chromatography-tandem Mass Spectrometry avoiding Derivatization Step, Analytical Methods, 2018, 10, 3968

12.Li, Xiuqin; Zhang, Qinghe; Li, Hongmei; Li, Mengwan; Wong, Siu-kay; Lee, Foo-Wing; Kakoulides, Elias; Naujaus, Evaldas; Fernandes-Whaley, Maria; Prevoo-Franzsen, Des; Quinn, Laura; Pookrod, Preeyaporn; Konopelko, Leonid. CCQM-K103 key comparison melanine in milk powder. Metrologia, 2017, 54(1A), 08018.

13.Li, X.; Li, H.; Li, X.; Zhang, Q., Determination of trace patulin in apple-based food matrices. Food Chemistry 2017, 233, 290-301.

14.Li, X.; Ma, W.; Li, H.; Ai, W.; Bai, Y.; Liu, H., Sampling and analyte enrichment strategies for ambient mass spectrometry. Anal. Bioanal. Chem. 2017, 410 (3), 715-724.

15.Xiu Qin Li, Qing He Zhang, Zong Yang, Hong Mei Li, Dong Feng Huang. The effects of isotope-labeled analogs on the LC-IDMS measurement by comparison of ESI responses and matrix effect of melamine, 13C3-melamine, 13C3+15N3-melamine, and 15N3-melamine. Anal. Bioanal. Chem. 2017, 409, 3233-3243.

16.Fangyuan Gao, Quanqing Zhang, Xiuqin Li, Qinghe Zhang, Ting Mao, Yong Lu, Weibing Zhang, Hongmei Li. Comparison of standard addition and conventional isotope dilution mass spectrometry for the quantification of endogenous progesterone in milk. Acred Qual Assur. 2016, 21, 395–401.

17.Fang Yuan Gao, Ling Yi Zhang, Xiu Qin Li, Wei Bing Zhang, Qing He Zhang. Study on diffusion behavior of analyte in electrospray ionization source. Rapid Commun. Mass Spectrom. 2016, 30 (Suppl. 1), 1–4.

Fangyuan Gao, Lingyi Zhang, Xiuqin Li, Fenglong Jiao, Weibing Zhang, Qinghe Zhang. A Refined Model for Ionization of Small Molecules in Electrospray Mass Spectrometry. Chem. Lett. 2016, 45, 955–957.

19.Quanqing Zhang, Qinghe Zhang, Zhichao Xiong, HaoWan, Xiaoting Chen, Hongmei Li, HanfaZou. Facile preparation of mesoporous carbon–silica-coated graphene for the selective enrichment of endogenous peptides. Talanta, 2016, 146, 272–278.

20.Hai Lu, Chao Wei, Hui Fu, Xiuqin Li, Qinghe Zhang, Jun Wang. Identification of Recycled Cooking Oil and Edible Oils by Iodine Determination and Carbon Isotopic Analysis. J Am Oil Chem Soc. 2015, 92, 1549–1553.

21.Jing Wang, Xiaomin Li, Qinghe Zhang, Jinping Xiong, Hongmei Li. Determination of phthalate esters in Chinese spirits using isotope dilution gas chromatography with tandem mass spectrometry. J. Sep. Sci. 2015, 38(10), 1700-1710.

22.Kang Ma, Xiao-jia Li. Rapid and Sensitive Method for the Determination of Eight Food Additives in Red Wine by Ultra-performance. Food Analytical Methods. 2015, 8(1): 203-212.

23.Quanqing Zhang, Qinghe Zhang, Zhichao Xiong, Hao Wan, Xiaoting Chen, Hanfa Zou. Facile preparation of carbon-functionalized ordered magnetic mesoporous silica composites for highly selective enrichment of N-glycans. RSC Adv. 2015, 5, 68972-68980.

24.Xiu Qin Li, Qing He Zhang, Kang Ma, Hong Mei Li, Zhen Guo. Identification and determination of 34 water-soluble synthetic dyes in foodstuff by high performance liquid chromatography–diode array detection–ion trap time-of-flight tandem mass spectrometry. Food Chemistry. 2015, 182, 316–326.

25.Xiu Qin Li, Zong Yang, Qing He Zhang, Hong Mei Li. Evaluation of matrix effect in isotope dilution mass spectrometry based on quantitative analysis of chloramphenicol residues in milk powder. Analytica Chimica Acta. 2014, 807,75– 83.